Effects of Acute Dehydration on the Kidney in Solitary Kidney Rats With Chronic Partial Ureteral Obstruction

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Aziz Serhat Baykara, Mete Kaya, Çiğdem Arslan Alıcı

Volume 8 · Issue 4 · pp. 519–523

Received: 20251127  Accepted: 20251231  Published: 20251231

Abstract

Aim: In this study, we evaluated the effects of dehydration on the kidney in rats with a single kidney subjected to experimentally-induced partial ureteral obstruction.Materials and Methods: Twenty male Wistar albino rats were randomly assigned to four groups of five animals each: Group 1, right nephrectomy (control); Group 2, right nephrectomy + dehydration; Group 3, right nephrectomy + left partial ureteral obstruction; and Group 4, right nephrectomy + left partial ureteral obstruction + dehydration. Chronic partial ureteral obstruction was induced by embedding the left ureter into the psoas muscle for four weeks. Dehydration was achieved via 48-hour water restriction. Results: Hematocrit, urine density, and blood urea levels were significantly increased in the dehydration groups, whereas blood creatinine was significantly elevated only in Group 4 (p=0.01). Scintigraphic evaluation demonstrated that glomerular filtration rate decreased in all experimental groups, with the lowest value observed in Group 4 (p=0.01). All experimental groups showed significant prolongation of Tmax and renal perfusion time and a decrease in renal uptake compared to the control group. These changes were most pronounced in Group 4 (p=0.01). Histopathological examination revealed that alterations such as papillary and tubular deformities, granulocyte accumulation, and medullary edema were more pronounced in rat samples from Group 4 compared to the other groups.Conclusion: Chronic partial ureteral obstruction in rats with a single kidney adversely affected renal structure and function, and the addition of acute dehydration further exacerbated this damage.

Keywords: Partial ureteral obstruction; dehydration; renal function; histopathology; kidney

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Cite this article

Aziz Serhat Baykara, Mete Kaya, Çiğdem Arslan Alıcı. Effects of Acute Dehydration on the Kidney in Solitary Kidney Rats With Chronic Partial Ureteral Obstruction. Journal of Cukurova Anesthesia and Surgical Sciences. 8(4):519-523. https://doi.org/10.36516/jocass.1831678

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