Effect of Prophylactic Vitamin D Supplementation on Postoperative Pain and Sedation in Children with Mental Motor Retarded Who Undergoing Dental Treatment Introduction

Aim: The frequency of vitamin D deficiency is higher in childre n with mental motor retardation (MMR). We aimed to investigate the effect of vitamin D supplementation on postoperative pain in children with MMR who underwent dental treatment under general anesthesia. Methods: Dental treatment was planned for a total of 62 patients with MMR, aged 7 -17 years. Participants were divided into two groups. Children were prescribed vitamin D (600 IU of vitamin D per day) or Saline. Serum vitamin D levels were measured. Participants continued to intake oral vitamin D 600 IU (Group D) or 2 ml saline (Group C) throughout 12 week s. All participants were observed postoperative 1st hour, and Non -communicating Children's Pain Checklist–Postoperative Version (NCCPC -PV), Ramsay seda tion scores, length of stay in post-anesthesia care unit, and analgesic requirements were recorded. Results: The study was completed with fifty children (35 in Group D, 15 in Group C). Serum vitamin D levels were higher in Group D than Group C at 12 weeks(p=0.007). Vitamin D deficiency was found at 13 patients (37.1%) and 6 (40%), and vitamin D sufficiency was found 18 (51.4%) and 7 (46.7%) in Groups D and C, respectively at first admission . There was s tatistically significant difference between groups in NCCPC -PV score at 15th, 30 th and 60 th minutes in PACU(p<0.05). However, Ramsey scores were similar between two groups at all times. Conclusions: Serum vitamin D levels were found to be low in MMR children. It was observed that vitamin D supplementation could reduce pain scores in 1st postoperative hour.