Demir eksikliği anemisinde demir tedavisi sonrası B12 vitamini ve folik asit seviyeleri

Background: In this study, our intent was to determine whether serum levels of B12 and folic acid in patients diagnosed with iron deficiency anemia undergo change in response to iron supplements. Methods: In this retrospective study, 202 female patients with iron deficiency anemia and only iron treatment were included. Complete blood count, vitamin B12, ferritin, folate levels of patients at the time of initial presentation and 4-8 weeks after treatment were examined. Results: Overall, significant increases were detected in mean hemoglobin, mean hematocrit, mean mean corpuscular volume, median white blood cell and median serum ferritin levels in all patients treated with iron therapy (both oral and intravenous); significant decreases were observed in post-treatment median platelet, median folate, and median B12 levels in this patient cohort. Conclusions: We conclude that deficiencies in serum levels B12, folate and iron, which are critical factors promoting erythropoiesis may effectively mask one another in a basic clinical assessment of anemia.